PROSPECT Trial Publications

As of May 2nd, 2018

Abstracts:

  1. Wheeler KE, Calce A, Cook DJ, Mehta S, Perreault MM, Thiboutot Z, Guenette M, Cho A, Burry L, for the PROSPECT Investigators and the Canadian Critical Care Trials Group. Survey of Canadian Intensive Care Unit Pharmacists’ Attitudes, Knowledge, and Use of Probiotics for Patients (Pro-Surve).  TechValueNet Meeting, Toronto, ON, September 23, 2014.
  2. Wheeler KE, Calce A, Cook DJ, Mehta S, Perreault MM, Thiboutot Z, Guenette M, Cho A, Burry L, for the PROSPECT Investigators and the Canadian Critical Care Trials Group. Survey of Canadian Intensive Care Unit Pharmacists’ Attitudes, Knowledge, and Use of Probiotics for Patients (Pro-Surve).  Canadian Critical Care Forum, Toronto, ON, October 28, 2014. Can Crit Care Forum Abstract Book 2014.
  3. Lamarche D, Rossi L, Shah M, Zytaruk N, Clarke F, Hand L, Lee J, Lee Y, Smith O, Jakab M, Shah S, Breton SJ, Langlois H, Porteous R, Watpool I, Acres S, Foster F, Meade M, Marshall JC, Lauzier F, Mehta S, McIntyre LL, Pagliarello G, Henderson W, Johnstone J, Heyland D, Thebane L, Bowdish D, Cook DJ, Surette M, for the PROSPECT Investigators and the Canadian Critical Care Trials Group. Quality Control In the Conduct of a Probiotic Randomized Trial. Can Crit Care Forum, Toronto, ON, October 28, Can Crit Care Forum Abstract Book 2014.
  4. Cook D, Johnstone J, Marshall J, Lauzier F, Thabane L, Mehta S, Dodek P, McIntyre L, Pagliarello G, Henderson W, Taylor R, Cartin-Ceba R, Goyal E, Herridge M, Wood G, Ovakim D, Karachi T, Surette M, Bowdish D, Lamarche D, Verschoor C, Duan E, Heels- Ansdell, Meade M, for the PROSPECT Investigators and the Canadian Critical Trials Group. Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial – PROSPECT: A Pilot Trial. Can Crit Care Forum, Toronto, ON, October 25, 2015. Can Crit Care Forum Abstract Book 2015.
  5. Verschoor CP, Lamarche D, Shah M, Bowdish D, Surette M, Clarke F, Zytaruk N, Hand L, Naidoo A, Thevaranjan N, Loukov D, Novakowski K, Dorrington MG, Malik M, McDonald E, Hoad N, K Wachmann, Meade MO, Marshall JC, Ansdell D, Cook DJ, for the PROSPECT Investigators and the CCCTG. Translational Biology Specimen Handling in the ICU: Procedures for a Multicenter Mechanistic Substudy. Presented at the Critical Care Canada Forum, Oct 26, 2015, Toronto, Ontario. Can Crit Care Forum Abstract Book 2015. Station # 2, E Poster # 14
  6. Zytaruk N, Shears M, Cook D, Saunders L, Krause C, Tremblay MC, Alcuaz V, Heels-Ansdell D, for the PROSPECT-TIMES Investigators, PROSPECT Investigators and the CCCTG. PROSPECT-TIMES: Probiotics to prevent Severe Pneumonia & Endotracheal Colonization Trial – Time In Motion Evaluation Study. [Abstract] Presented at the Critical Care Canada Forum, Oct 26, 2015, Toronto, Ontario. Can Crit Care Forum Abstract Book 2015. Station #4, E Poster # 28
  7. Dionne J, Saunders L, Duan E, Sullivan K, Takaoka A, Heels-Ansdell D, Zytaruk N, Cook D, for the PROSPECT Investigators and the CCCTG. Diarrhea During Critical Illness: A Pilot Study. Crit Care Med 2015;43(12):suppl A374.
  8. Shears M, Clarke F, Dodek P, O’Brien J, Meade L, Foster D, Smith O, Mehta S, Cook D, for the PROSPECT Investigators and the CCCTG. Inter-Prob:INTERviewing substitute decision makers about PROBiotics. Crit Care Med 2015;43(12):suppl A462.
  9. Saunders L, Clarke F, Johnstone J, Hand L, Jakab M, Watpool I, Good J, Heels-Ansdell D, for the PROSPECT (Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization) Trial Investigators and the Canadian Critical Care Trials Group. Screening Weeks: A Pilot Trial Management Metric. Crit Care Med 2015;43(12):suppl A4282
  10. Duan E, Rochwerg B, Centofanti J, Dionne J, Saunders L, Meade M, Johnstone J, Cook D, for the PROSPECT Investigators and the CCCTG. Pneumonia in the ICU: Variable rates based on different definitions. Crit Care Med 2015;43(12):suppl A671.
  11. Lamarche D, Rossi L, Fontes M, Verschoor C, Bowdish D, Clarke F, Zytaruk N, Hand L, McDonald E, Hoad N, Wachmann K, Johnstone J, Meade MO, Marshall JC, Karachi T, Ansdell D, Cook DJ, Surette M, for the PROSPECT Investigators & CCCTG. Loss of microbial distinction between anatomical sites sites in critically ill patients. 2016 Mucosal Immunology Course & Symposium Abstract Book #F79.
  12. Duan EH, Johnstone J, Meade MO, Marshall JC, Lauzier F, Mehta S, Dodek PE, McIntyre L, Hall R, Ovakim D, G Wood, G Pagliarello, W Henderson, E Goyal, M Herridge, T Karachi, F Lamontagne, R Zarychanski, E Charbonneau, R Taylor, R Cartin-Ceba, DJ Cook, for the PROSPECT Investigators and the CCCTG. Refining exclusion criteria following pilot trials: Lessons from PROSPECT. Canadian Critical Care Forum 2016, Toronto, ON, October 2016. Can Crit Care Forum Abstract Book 2016.
  13. Verschoor CP, Loukov D, Novakowski KE, Naidoo A, Thevaranjan N, Dorrington MG, Malik M, Lamarche D, Surette M, Clarke F, Zytaruk N, Hand L, McDonald E, Hoad N, Wachmann KA, Johnstone J, Meade MO, Marshall JC, Karachi T, Charbonney E, Ansdell D, Cook DJ, Bowdish DME, for the PROSPECT Investigators and the Canadian Critical Care Trials Group. Circulating Inflammatory and Immunomodulatory Mediators in Critically Ill Patients. Canadian Critical Care Forum 2016, Toronto, ON, October 2016 Can Crit Care Forum Abstract Book 2016.
  14. Zytaruk N, Clarke F, Saunders L, Foster D, Alcuaz V, Good J, Auld F, Henderson W, Dodek P, Wood G, Ovakim D, S Reynolds, Duan E, Rochwerg B, Dionne J, Centofanti J, Heels-Ansdell D, Morris A, Garber G, Marshall JC, Meade MO, Lauzier F, Thebane L, Mehta S, Herridge M, Golan E, McIntyre L, Pagliarello G, Karachi T, Johnstone J, Cook D, for the PROSPECT British Columbian Collaborators, Methods Center, and the Canadian Critical Care Trials Group. Antimicrobial use in mechanically ventilated patients: Opportunities for enhanced antimicrobial stewardship. Canadian Critical Care Conference Whistler, BC. Whistler Abstract Book 2017.
  15. Dionne JC, Duan E, Johnstone J, Meade MO, Lauzier F, Marshall JC, Saunders L, Anderson S, Zytaruk N, Clarke F, Heels-Ansdell D, Cook D, for the PROSPECT Investigators and the Canadian Critical Care Trials Group. Diarrhea and Clostridium difficile infection in the ICU: A Multicenter Study. Gastroenterology 2017, 152,(5), supplement 1, S942.
  16. Shears M, Takaoka A, Millen T, Clarke F, Holding A, Tharmalingham S, Rochwerg B, Li G, Thabane L, Woo T, Muscedere J, Rockwood K, Bagshaw SM, Cook D, for the PROSPECT Investigators and the CCCTG. Considering Frailty in Individuals of All Ages in the Intensive Care Unit. Canadian Frailty Network Abstract, Toronto, ON. April 23-24, 2017.
  17. Takaoka A, Shears M, Millen T, Holding A, Tharmalingham S, Clarke F, Rochwerg B, Li G, Thabane L, Woo T, Rockwood K, Bagshaw SM, Johnstone J, Cook D, for the PROSPECT Investigators and the CCCTG. Evaluating the Chart Review-Based Clinical Frailty Scale in the Intensive Care Unit (ICU). Canadian Frailty Network Abstract, Toronto, ON. April 23-24, 2017.
  18. Tharmalingam S, Takaoka A, Shears M, Millen T, Holding A, Clarke F, Rochwerg B, Li G, Thabane L, Rockwood K, Bagshaw S, Cook D, for the PROSPECT Investigators and the CCCTG. Evaluating the Clinical Frailty Score in the Intensive Care Unit (ICU). Canadian Geriatrics Society Conference Abstract 2017.
  19. Takaoka A, Shears M, Millen T, Holding A, Clarke F, Tharmalingam S, Li G, Thabane L, Bagshaw SM, Rockwood K, Stelfox T, Muscedere J, Johnstone J, Cook D, for the PROSPECT Investigators and the CCCTG. The Prognostic Implications of Chart Review-Based Clinical Frailty Scale Scores in the ICU. Canadian Critical Care Forum 2017. Can J Anesthesia 2017.
  20. Lamarche D, Zytaruk N, Szamosi J, Arabi Y, Al Anizi H, Gramish J, Johnstone J, Cook D, Surette M for the PROSPECT Investigators and the CCCTG. PROSPECT-TSS  (PROSPECT-Temperature Stability Substudy) Canadian Critical Care Forum 2018. Toronto, ON, November 2018 Can Crit Care Forum Abstract Book (in submission).

Manuscripts:

  1. Johnstone J, Meade M, Marshall J, Heyland DK, Surette M, Bowdish D, Lauzier F, Thabane L, Cook DJ for the PROSPECT Investigators and the Canadian Critical Care Trials Group. Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial: PROSPECT: Protocol for A Feasibility Randomized Pilot Trial. Pilot and Feasibility Studies 2015. 1:19. DOI 10.1186/s40814-015-0013-3.
  2. Cook D, Johnstone J, Marshall JC, Lauzier F, Thabane L, Mehta G, Dodek PE, McIntyre LL, Pagliarello G, Henderson W, Taylor RW, Cartin-Ceba, R, Golan E, Herridge M, Wood G, Ovakim D, Karachi T, Surette MG, Bowdish DME, Lamarche D, Verschoor CP, Duan EH, Heels-Ansdell D, Arabi Y, Meade MO for the PROSPECT Investigators and the Canadian Critical Care Trials Group. Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial – PROSPECT: A Pilot Trial. Trials 2016;17:377.
  3. Shears M, Takaoka A, Rochwerg B, Bagshaw SM, Johnstone J, Holding A, Tharmalingam S, Millen T, Clarke F, Rockwood K, Li G, Thabane L, Muscedere J, Stelfox HT, Cook DJ, for the PROSPECT Investigators and the Canadian Critical Care Trials Group. Assessing Frailty in the Intensive Care Unit: A Reliability and Validity Study. J Critical Care 2018;45:197-203. doi: 10.1016/j.jcrc.2018.02.004.